Warbixin guud
Pepsinogen I, horudhacyada pepsin, waxaa soo saara xabka caloosha oo lagu sii daayaa lumen gastric iyo wareegga wareegga.Pepsinogen wuxuu ka kooban yahay hal silsilad polypeptide ah oo ah 375 amino acids oo leh celcelis miisaan kelli ah 42 kD.PG I (isoenzyme 1-5) waxaa inta badan sir ah unugyada madaxa ee xuubka fundic, halka PG II (isoenzyme 6-7) ay qarsoodi yihiin qanjidhada pyloric iyo xuubka duodenal ee u dhow.
Hordhac wuxuu ka tarjumayaa tirada unugyada dusha caloosha iyo sidoo kale unugyada qanjidhada, wuxuuna si aan toos ahayn ula socdaa atrophy gastric.Waxay sidoo kale si aan caadi ahayn u deggan yihiin sababtoo ah waxay shaqadooda ku qabtaan xaaladaha adag ee ka jira habka dheef-shiidka.Atrophy ee xuubka corpus wuxuu keenaa isku-dhafka hoose ee pepsinogen I oo markaa hoos u sii daaya serum.Serum pepsinogen I waxay muujisaa shaqada iyo xaaladaha xuubka caloosha.
Lammaanaha Talada | CLIA (La-qabsashada): 1C1-3 ~ 1G7-3 1E3-1 ~ 1G7-3 |
daahirnimo | >95%, waxaa go'aamiyay SDS-PAGE |
Habaynta kaydka | 20mM PB, 150mM NaCl, 0.1% Proclin 300, pH7.4 |
Kaydinta | Ku kaydi xaaladaha nadiifka ah -20 ℃ ilaa -80 ℃ markaad hesho. Waxaan ku talinaynaa in loo qaybiyo borotiinka tiro yar si loo kaydiyo ugu fiican. |
Magaca Alaabta | BisadMaya | Aqoonsiga Clone |
PGI | AB0005-1 | 1C1-3 |
AB0005-2 | 1E3-1 | |
AB0005-3 | 1G7-3 |
Fiiro gaar ah: Bioantibody waxa lagu beddeli karaa tiro marka loo eego baahidaada.
1.Sipponen P, Ranta P, Helske T, iyo al.Heerarka serum ee gastrin-17 amided iyo pepsinogen I ee gastritis atrophic: daraasad kiis-koontorool oo indho-indhayn ah.[J].Joornaalka Iskandaneefiyanka ee Gastroenterology, 2002, 37 (7): 785-791.
2.Mangla JC, Schenk EA, Desbailets L, iyo al.Dheecaanka Pepsin, pepsinogen, iyo gastrin ee hunguriga Barrett.Astaamaha bukaan-socodka iyo morphological[J].Gastroenterology, 1976, 70 (5 PT.1): 669-676.