Ka-hortagga aadanaha RBP4 Antibody, Mouse Monoclonal

Warbixin guud
Retinol-binding protein 4 (RBP4) waa sidaha gaarka ah ee retinol (sidoo kale loo yaqaan fitamiin A), wuxuuna mas'uul ka yahay beddelka retinol aan xasilloonayn oo aan milmi karin ee xalka aqueous ee isku dhafan oo isku dhafan oo plasma ah iyada oo loo marayo isdhexgalka adag.Xubin ka mid ah qoyska superfamily ee lipocalin, RBP4 oo ka kooban qaab-dhismeedka β-barrel oo leh dalool si fiican loo qeexay ayaa laga siidaayaa beerka, oo iyaduna waxay keentaa retinol kaydka beerka ilaa unugyada durugsan.Plasma dhexdeeda, isku-dhafka RBP4-retinol wuxuu la falgalaa transthyretin (TTR), xidhitaankan ayaa muhiim u ah ka hortagga qashin-saarka RBP4 iyada oo loo marayo glomeruli kelyaha.RBP4 oo laga soo xigtay isha ectopic waxay si hufan u gudbisaa retinol indhaha, iyo yaraanteedu waxay si weyn u saamaysaa aragga habeenkii.Dhawaan, RBP4 sida adipokine, waxaa lagu ogaadaa in lagu muujiyay unugyo adipose ah oo la xidhiidha cayilka, caabbinta insulin (IR) iyo nooca 2 ee sonkorowga (T2DM).