Warbixin guud
S100B waa borotiin ku xidhan kaalshiyam, kaas oo laga soo saaro astrocytes.Waa borotiin yar oo cytosolic dimeric ah (21 kDa) oo ka kooban ββ ama αβ silsilado.S100B waxay ku lug leedahay hawlo kala duwan oo ka mid ah unugyada gudaha iyo kuwa ka baxsan unugyada.
Tobankii sano ee la soo dhaafay, S100B waxay u soo baxday sidii musharrax biomarker-ka-hortagga dhiigga-maskaxda (BBB) dhaawaca iyo dhaawaca CNS.Heerarka sare ee S100B waxay si sax ah u muujinayaan jiritaanka xaaladaha neerfaha oo ay ku jiraan dhaawac madaxa ah iyo cudurrada neerfayaasha.Heerarka caadiga ah ee S100B ayaa si la isku halleyn karo uga saaraya cudurka CNS ee waaweyn.Serum S100B ayaa sidoo kale lagu soo warramey inay tahay calaamad waxtar u leh ogaanshaha hore ee metastases ee melanoma iyo dhibaatooyinka maskaxda ee ka yimaada dhaawaca madaxa, qalliinka wadnaha, iyo istaroogga degdega ah.
Lammaanaha Talada | CLIA (La-qabsashada): 5H2-3 ~ 22G7-5 22G7-5 ~ 5H2-3 |
daahirnimo | >95% sida ay go'aamisay SDS-PAGE. |
Habaynta kaydka | 20mM PB, 150mM NaCl, 0.1% Proclin 300, pH7.4 |
Kaydinta | Ku kaydi xaaladaha nadiifka ah -20 ℃ ilaa -80 ℃ markaad hesho. Waxaan ku talinaynaa in loo qaybiyo borotiinka tiro yar si loo kaydiyo ugu fiican. |
Magaca Alaabta | BisadMaya | Aqoonsiga Clone |
s100 β | AB0061-1 | 5H2-3 |
AB0061-2 | 22G7-5 | |
AB0061-3 | 21A6-1 |
Fiiro gaar ah: Bioantibody waxa lagu beddeli karaa tiro marka loo eego baahidaada.
1. Ostendorp T, Leclerc E, Galichet A, iyo al.Fikradaha qaab dhismeedka iyo shaqada ee firfircoonida RAGE ee multimeric S100B[J].Joornaalka EMBO, 2007, 26(16):3868-3878.
2. R, D, Rothoerl, iyo al.Heerarka serum S100B oo sarreeya ee bukaannada dhaawacyada qaba ee aan madaxa dhaawacmin.[J].Qalliinka neerfaha, 2001.