Ka-hortagga aadanaha TIMP1 Antibody, Mouse Monoclonal
Faahfaahinta alaabta
Warbixin guud
TIMP metallopeptidase inhibitor 1, oo sidoo kale loo yaqaan TIMP-1/TIMP1, Collagenase inhibitor 16C8 fibroblast Erythroid-ka firfircoonida, TPA-S1TPA-ku-soo-baxa proteinTissue inhibitor of metalloproteinases 1, waa xakameyn dabiici ah oo ka mid ah matrix metalloproteinases (koox) ku lug leh hoos u dhigista matrix-ka unugyada ka baxsan.TIMP-1/TIMP1 waxaa laga helaa unugyada uurjiifka iyo dadka waaweyn.Heerarka ugu sarreeya waxaa laga helaa lafaha, sambabada, ugxan-sidaha iyo ilmo-galeenka.Isku-dhafan leh metalloproteinases oo si aan leexleexad lahayn u hawl-gelisa iyaga oo ku xidha cofactor-kooda zinc-ka.TIMP-1/TIMP1 waxay dhexdhexaadisaa erythropoiesis in vitro;laakiin, si ka duwan IL-3, waa nooc-gaar ah, kicinta korriinka iyo kala duwanaanta kaliya ee aadanaha iyo murine erythroid progenitors.Marka lagu daro doorkeeda ka-hortagga ee ka dhanka ah inta badan MMP-yada la yaqaan, borotiinku wuxuu awood u leeyahay inuu kor u qaado kororka unugyada noocyo badan oo unugyo ah, waxaana laga yaabaa inuu sidoo kale yeesho shaqo ka hortag-apoptotic ah.Qorista hidda-sidaha borotiinkan ayaa si aad ah loo dami karaa iyadoo laga jawaabayo cytokines iyo hormoonno badan.Intaa waxaa dheer, muujinta qaar laakiin ma aha dhammaan koromosoomyada X aan firfircoonayn waxay soo jeedinaysaa in firfircoonida hidde-sidahani uu yahay polymorphic dheddigga aadanaha.Hidde-sidaha codaynta wuxuu ku dhexyaal gudaha gudaha 6 ee hiddasidaha synapsin I waxaana loo qoraa jihada ka soo horjeeda.Isku-dhafan leh metalloproteinases oo si aan leexleexad lahayn u hawl-gelisa iyaga oo ku xidha cofactor-kooda zinc-ka.TIMP-1/TIMP1 waxaa loo yaqaanaa inuu ku dhaqmo MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 iyo MMP-16.
Guryaha
| Lammaanaha Talada | CLIA (La-qabsashada): 1D5-5 ~ 3G11-6 1D12-2 ~ 1G3-7 |
| daahirnimo | >95% sida ay go'aamisay SDS-PAGE. |
| Habaynta kaydka | PBS, pH7.4. |
| Kaydinta | Ku kaydi xaaladaha nadiifka ah -20 ℃ ilaa -80 ℃ markaad hesho. Waxaan ku talinaynaa in loo qaybiyo borotiinka tiro yar si loo kaydiyo ugu fiican. |
Isbarbardhigga Tartanka
Macluumaadka Dalabka
| Magaca Alaabta | BisadMaya | Aqoonsiga Clone |
| TIMP1 | AB0034-1 | 1D5-5 |
| AB0034-2 | 1D12-2 | |
| AB0034-3 | 1G3-7 | |
| AB0034-4 | 3G11-6 |
Fiiro gaar ah: Bioantibody waxa lagu beddeli karaa tiro marka loo eego baahidaada.
Xigasho
1.Barylski M, Kowalczyk E, Szadkowska I, iyo al.[Cudurka difaaca jirka ee metalloproteinases[J].Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego, 2011, 30 (178): 246-8.
2.Hayakawa T, Yamashita K, Tanzawa K, iyo al.Dhaqdhaqaaqa kor u qaadista korriinka ee xakameynaya unugyada metalloproteinase-1 (TIMP-1) ee unugyo kala duwan oo suurtagal ah oo cusub oo suurtagal ah ee serumWarqadaha FEBS, 1992, 298.
3.Haider DG, Karin S, Gerhard P, iyo al.Serum retinol-binding borotiinka 4 waa la dhimay ka dib miisaan lumis ee maadooyinka cayilka ah.[J].Journal of Clinical Endocrinology & Metabolism (3): 1168-71.
